Application of mifepristone combined with rivanol in midtrimester induction of labor
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摘要: 目的：探讨米非司酮联合利凡诺在中期妊娠引产中的临床疗效。方法需要引产的患者100例，随机分为实验组和对照组，各50例。对照组单纯给予利凡诺75 mg 羊膜腔内注射，实验组先给予利凡诺75 mg 羊膜腔内注射，同时空腹口服米非司酮75 mg，24 h 后再空腹口服75 mg。观察2组宫颈 Bishop 评分、宫缩发动时间、排胎时间、总产程、流产效果、产后出血量、副作用。结果用药后，实验组宫颈评分明显高于对照组；用药后，实验组宫缩发动时间、排胎时间、总产程较对照组明显减少。实验组引产有效率为100％，高于对照组引产有效率（92．0％），但2组比较差异无统计学意义。实验组产后出血量明显少于对照组。结论利凡诺联合米非司酮应用于中止中期妊娠，可更为有效地软化宫颈，缩短胎儿娩出时间，减少患者痛苦和相关并发症，改善产后恢复，是值得在临床上推广的引产方法。Abstract: Objective To explore the clinical efficacy of mifepristone combined with rivanol in induction of labor.Methods 100 patients requiring induction of labor were randomly divided in-to experimental group and control group with 50 patients in each group.The control group was giv-en intra-amniotic injection of 75 mg rivanol,while the patients in the experimental group orally took 75 mg mifepristone under fasting condition based on the therapy in the control group,and took another 75 mg after 24 hours.The score of cervical Bishop,onset time of uterus contraction,time to eliminate the fetus,total stage of labor,abortion effect,amount of postpartum hemorrhage and side effects were all observed in the two groups.Results After administration of the drugs,the score of cervical Bishop in the experimental group was markedly higher than that in the control group,while onset time of contraction,time to eliminate the fetus,total stage of labor and amount of postpartum hemorrhage were obviously less than that in the control group.The response rate of induction of labor in experimental group (1 0 0 % )was higher than that in the control group (92.0%),the difference was statistically significant.Conclusion Application of mifepristone com-bined with rivanol to terminate the pregnancy can effectively soften the cervix,shorten the time of delivery of baby,reduce patients′pain and relevant complications and ameliorate postpartum recov-ery,so it is worthy of clinically popularization.
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Keywords:
- rivanol /
- mifepristone /
- midtrimester pregnancy /
- induction oflabor
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