Abstract: Objective To explore the nursing intervention on pregnancy rate and endocrine indexes in obese patients with polycystic ovary syndrome(PCOS)combined with infertility.Meth-ods 40 infertile patients with polycystic ovary syndrome were randomly divided into control group and observation group.Control group was given the therapy of medication induced ovulation while the observation group was given nursing intervention before treatment for four months in advance. The pregnancy rate and endocrine index were compared.Results The pregnancy rate in the ob-servation group was 45%(9 /20)which was significantly higher than 15%(3 /20)in the control group.The difference was statistical significant(P <0.05).Through nursing interventions,obesi-ty,polycystic ovary syndrome,infertility endocrine indexes including testosterone (T),luteinizing hormone (LH),LH /FSH and insulin resistance index (HOMA-IR)had changed compared with the condition before.The difference was significant.Conclusion The systematic nursing inter-vention is significant on polycystic ovary syndrome,particularly for obese women with polycystic o-vary syndrome.It could increase pregnancy rates,endocrine metabolism,lifestyle and mental health,so it is worthy of promotion.