Abstract: Objective To explore the types of allergen in allergic children with different age in Nantong region.Methods Serum allergen test system was used to detect specific IgE and total IgE in 218 cases,and skin prick and serum immune strap mark experiment were used in 28 cases. Results Allergen of inhalation was observed in 114 cases(52.4%)and food allergen was observed in 101 cases(46.3%),and there were significant differences in different age groups.Aeroallergen was observed in 17 cases(19.3%)and food allergen was observed in 45 cases(51.1%)in infant groups,and there was significant difference (P <0.01 ),but there was no significant difference in child group(P >0.05 ).In the elder children,there were significant differences (P <0.05 )of aeroallergen and food allergen.There were no significant difference of sensitivity and specificity be-tween skin prick test and serum immune strap mark experiment (P >0.05).Conclusion The food allergen is the most common allergen in infants and the aeroallergen is the common allergen in teen-age.The main food allergens are egg and sea food,the main aeroallergens are dust mites and house dust.