Abstract: Objective To explore the influence of arterial thrombolysis combined with uri-nary kallidinogenase on the prognosis of patients with acute posterior circulation cerebral infarction (PCCI).Methods 40 patients with acute PCCI and arterial thrombolysis were randomly divided into treatment group 1 and 2,20 cases in each group.Both groups were treated with arterial throm-bolysis,whereas treatment group 1 was given urinary kallidinogenase for 14 days after that.Mean-while,20 patients refusing to undergo arterial thrombolysis were selected as control group and were given routine conservative treatment.14 days after treatment,the clinical efficacy,NIHSS score and ADL score as well as adverse reactions were compared among 3 groups.Results The clinical improvement rates in treatment group were obviously higher than control group,and mortality was significantly lower than control group.After treatment,NIHSS and ADL scores in treatment group 1 and 2 were improved significantly by comparison with control group,and the improved degrees of NIHSS and ADL in treatment group 1 were notably and slightly greater than treatment group 2. Conclusion Arterial thrombolysis combined with urinary kallidinogenase can significantly amelio-rate the prognosis of patients with acute PCCI and shows a better efficacy than single arterial throm-bolysis without increasing the incidence rate of the adverse reactions.