Abstract: Objective To explore the application effect of nutrition support nursing with homogenized diet in improving the nutrition and immune state in ICU patients.Methods 250 ICU patients were randomly divided into observation group and control group.The control group was given parenteral nutrition within 72 hours in ICU while the observation group was given the homogenate diet nutrition within 72 hours in ICU.Nursing effect was compared between the two groups.Results Counts of total serum protein,albumin,hemoglobin and lymphocyte after 1 week in the observation group were higher than that in the control group,the difference was statis-tically significant(P <0.05).The difference was statistically significant since gastrointestinal dys-function rate,hospitalization time in ICU in the observation group were less than that in the con-trol group(P <0.05).The difference was not statistical significant in the complications and mortal-ity (P >0.05).Conclusion Homogenate nutritional support therapy can improve the nutritional and immune status of ICU patients and promote the patients’recovery.