Abstract: Objective To observe nursing intervention of elderly patients with painless gas-trocopy,and to sum up the nursing experience to prevent adverse reaction in elderly patients. Methods 70 elderly patients (≥ 60 years)undergoing painless gastroscopy were randomly divided into intervention group and control group.The patients in the control group (n =35)were given routine examination undergoing painless gastroscopy inspection while the patients in the interven-tion group (n =35)were carried out nursing intervention before,during and after the painless gas-troscopy inspection.Heart rate,systolic pressure,diastolic pressure and blood oxygen saturation at the three time points and other adverse reactions during the operation were compared in the two groups.Results The difference was statistically significant in heart rate,systolic pressure,dias-tolic pressure and blood oxygen saturation before and during the examination(P <0.05).The dif-ference was significant after comparison of the depression,anxiety and somatization rate in the in-tervention group and contrast group (P <0.05).The difference was statistically significant since the adverse reactions such as salivation,cough,nausea and malaise of the intervention group were less serious(P <0.05).Conclusion Nursing intervention can reduce anxiety and other adverse re-actions of the elderly patients with painless gastroscopy.