Abstract: Objective To explore the nursing experience of interventional therapy forisolat-ed superior mesenteric artery dissection(ISMAD).Methods The clinical material of 12 patients with ISMAD was retrospectively analyzed.Preoperative preparation,close coordination with doc-tors and strict postoperative nursing were the key to the operation.Results All patients were suc-cessfully implanted the stent without complication.Conclusion Percutaneous endovascular stent implantation is a reliable treatment for ISMAD and it provides security for patients in perioprative period.