Abstract: Objective To investigate cause and nursing strategy for hyponatremia patients with high paraplegia.Methods The materials of 51 high paraplegia patients with hyponatremia and risk factors of hyponatremia were retrospectively analyzed.Results There were 2 patients giving up the treatment and the sodium concentration of 49 patients returned to normal after treat-ment and nursing.Central origin in the spinal cord was the main cause of hyponatremia.Conclusion Hyponatremia is common in patients with high paraplegia.The vital signs,consciousness,urine and biochemical items should be monitored closely.Accurate nursing countermeasures could reduce the occurrence of hyponatremia,improve the life quality and survival rate of patients.