Abstract: Objective To investigate the effect of nursing intervention of hierarchy nursing in hand-foot-mouth disease(HFMD).Methods Nursing intervention and continuous improve-ment programs of HFMD in patients were retrospectively analyzed.Results Hierarchy nursing could improve the early detection rate of severe HFMD patients and reduce mortality.Conclusion Hierarchical management and appropriate nursing measures are conducive to confirm early severe (critical severe)HFMD children and improve the cure rate.