Abstract: Objective To investigate the influence of high maintenance clopidogrel on levels of platelet aggregation and hs-CRP in patients with acute myocardial infarction after PCI.Methods 78 patients with acute myocardial infarction after PCI were randomly divided into two groups. The control group was treated with routine maintenance dose (75 mg /d)of clopidogrel ,and the ob-servation group was treated with 150 mg /d.Platelet aggregation and hs-CRP levels before treatment and the occurrence of major cardiovascular events and bleeding rate were compared.Results There were no significant differences in platelet aggregation and serum hs-CRP level between the two groups before PCI(P >0.05),but which significantly reduced after operation (P <0.05),and the observation group was significantly lower than the control group (P <0.05).There were no signifi-cant differences in the primary endpoint event rate and minor bleeding rate between two groups(P >0.05).Conclusion The high maintenance dose of clopidogrelin (150 mg /d)can enhance the ef-fect of anti-platelet aggregation and reduce the patients’inflammatory response.