Influence of diltiazem intravenous infusion on the cardiac function of patients with cardiovascular disease
-
摘要: 目的：探讨地尔硫卓持续静脉泵入对于心血管疾病患者（扩张型心肌病、冠心病、高血压病）的心功能的影响。方法分析2012年3月-2014年1月在本院心内科接受住院治疗的心血管疾病患者的临床资料。入组患者根据病情诊断分为A（扩张型心肌病）、B（冠心病）、C（高血压病）三组。比较三组患者的 SBP（收缩压）、HR（心率）、IVSd（室间隔舒张末期厚度）、LVED（左室最大舒张末期内径）、LVPWd（左室后壁舒张末期厚度）、DT（E 峰减速时间）及 BNP 水平。结果本研究共纳入研究对象60例，其中 A、B、C 组各20例。A 组患者用药后的 LVPWd（t ＝2．530，P ＝0．016）、DT（t ＝8．040，P ＜0．01）水平均高于用药前，而 BNP（t ＝4．437，P ＜0．01）水平显著低于用药前。B 组患者用药后的 SBP（t ＝12．68，P ＜0．01）、HR（t ＝4．077， P ＜0．01）、DT（t ＝8．131，P ＜0．01）、BNP（t ＝13．19，P ＜0．01）水平均显著低于用药前。C 组患者用药后的 SBP（t ＝7．832， P ＜0．01）、HR（t ＝10．04，P ＜0．01）、DT（t ＝9．653，P ＜0．01）水平均显著低于用药前。结论对于扩张型心肌病、冠心病、高血压病的患者，地尔硫卓的持续静脉泵入对患者心脏的收缩功能无显著影响，而能够降低血压、心率，改善心肌缺血状况、心脏舒张功能。Abstract: Objective To analyze the impact of diltiazem intravenous infusion on the cardiac function of patients with cardiovascular disease.Methods Clinical materials of patients with cardio-vascular disease were retrospectively analyzed,and they were divided into group A (dilated car-diomyopathy),group B (coronary heart disease)and group C (hypertensive disease)according to the treatment.The levels of SBP,HR,IVSd,LVED,LVPWd,DT and BNP were analyzed and compared among three groups.Results A total of 60 patients were retrospective analyzed,includ-ing 20 in each group.The levels of LVPWd and DT in group A before the treatment were signifi-cantly higher than that after the treatment.The level of BNP in group A before the treatment was significantly lower than that after the treatment.The levels of SBP,HR,BNP and DT in group B before the treatment were significantly lower than that after the treatment.The levels of SBP,BNP and DT in group C before the treatment were significantly lower than that after the treatment.Con-clusion For the patients with dilated cardiomyopathy,coronary heart disease or hypertension, continuous intravenous infusion with diltiazem can reduce blood pressure and heart rate,and im-prove the status of myocardial ischemia and cardiac diastolic function.
-
Keywords:
- diltiazem /
- dilated cardiomyopathy /
- coronary heart disease /
- hypertension /
- cardiac function
-
-
Adibkia K, Shokri J, Barzegar-Jalali M. Effect of sol-vent type on retardation properties of diltiazem HCl form liqu-isolid tablets [J]. Colloids and Surfaces B-Biointerfaces, 2014.10. Campbell M, Ahluwalia J, Watson AC. Diltiazem-associated hyperpigmentation [J]. Journal of General Internal Medicine, 2013, (12):1676. Shah M, Sandler L, Rai V. Quality of compounded topical 2% diltiazem hydrochloride formulations for anal fis-sure [J]. World Journal of Gastroenterology, 2013, (34):5645. Chen P, Deng Z, Wang T. The potential interaction of MARCKS-related peptide and diltiazem on acrolin-induced airway mucus hypersecretion in rats [J]. Int Immunopharma-col, 2013(3):625. Bologa C, Lionte C, Coman A. Lipid emulsion therapy in cardiodepressive syndrome after diltiazem overdose-case re-port [J]. American Journal of Emergency Medicine, 2013(7):1154. Shojaee S, Asare-Addo K, Kaialy W. An investigation into the stabilization of diltiazem HCl release from matrices made from aged polyox powders [J]. AAPS PHARMSCITECH, 2013(3):1190. Adibkia K, Ghanbarzadeh S, Shokri MH. Micro-porous surfaces in controlled drug delivery systems:design and evalu-ation of diltiazem hydrochloride controlled porosity osmotic pump using non-ionic surfactants as pore-former [J]. Pharmaceutical Development and Technology, 2014(4):507. Jindal T, Mandal S N, Biswas G. Evaluation of the ef-ficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate [J]. Annals of the Royal College of Surgeons of England, 2013(5):361. Zheng T, Su C H, Zhao J. Effects of CYP3A5 and CYP2D6 genetic polymorphism on the pharmacokinetics of diltiazem and its metabolites in Chinese subjects [J]. PHARMAZIE, 2013(4):257. Qazi F, Shoaib MH, Yousuf R I. Formulation develop-ment and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4Mand K100M [J]. Pak J Pharm Sci, 2013(4):653. Ma MK, Kwan L P, Mok M M. Significant reduction of Tacrolimus trough level after conversion from twice daily Prograf to once daily Advagraf in Chinese renal transplant re-cipients with or without concomitant diltiazem treatment [J]. Renal Failure, 2013(7):942. Bulus H, Varol N, Tas A. Comparison of topical isosorbide mononitrate, topical diltiazem, and their combina-tion in the treatment of chronic anal fissure [J]. Asian J Surg, 2013(4):165. Bai Y, Hu L, Wu J. Effects of intravenous diltiazem in a rat model of experimental coronary thrombotic microembo-lism [J]. Exp Ther Med, 2013(4):873. -
期刊类型引用(5)
1. 刘培彩，陈倩，苏杨. 穴位贴敷联合电子无烟艾灸对慢性心力衰竭患者心脏功能及日常生活能力的影响. 中国医药指南. 2025(07): 156-158 . 
百度学术
2. 黄雨欣，杨帆，陈奇祺，廖佳颖，李潇杰，黎祖鸣，陈慧聪. 实脾散临床应用研究进展. 中国民族民间医药. 2024(03): 76-80 . 百度学术
3. 程虹，王长江，邹新蓉，薛雪，王小琴. 王小琴分期论治糖尿病肾病经验管窥. 中国医药导报. 2024(04): 143-147 . 百度学术
4. 张运娇，杨继，马腾，田昕彤，穆丽婷，赵英强. 经方治疗心力衰竭的研究现状. 中西医结合心脑血管病杂志. 2023(08): 1444-1450 . 百度学术
5. 史振红，周红妮，崔东. 实脾饮合肾气丸治疗慢性肾功能衰竭. 中医学报. 2022(09): 1977-1981 . 百度学术
其他类型引用(5)
计量
- 文章访问数: 197
- HTML全文浏览量: 37
- PDF下载量: 0
- 被引次数: 10
下载:
苏公网安备 32100302010246号
