Abstract: Objective To analyze the impact of diltiazem intravenous infusion on the cardiac function of patients with cardiovascular disease.Methods Clinical materials of patients with cardio-vascular disease were retrospectively analyzed,and they were divided into group A (dilated car-diomyopathy),group B (coronary heart disease)and group C (hypertensive disease)according to the treatment.The levels of SBP,HR,IVSd,LVED,LVPWd,DT and BNP were analyzed and compared among three groups.Results A total of 60 patients were retrospective analyzed,includ-ing 20 in each group.The levels of LVPWd and DT in group A before the treatment were signifi-cantly higher than that after the treatment.The level of BNP in group A before the treatment was significantly lower than that after the treatment.The levels of SBP,HR,BNP and DT in group B before the treatment were significantly lower than that after the treatment.The levels of SBP,BNP and DT in group C before the treatment were significantly lower than that after the treatment.Con-clusion For the patients with dilated cardiomyopathy,coronary heart disease or hypertension, continuous intravenous infusion with diltiazem can reduce blood pressure and heart rate,and im-prove the status of myocardial ischemia and cardiac diastolic function.