Abstract: Objective To explore the relationship of cognitive dysfunction and serum C-re-active protein (CRP)and uric acid (UA)levels in elderly patients with type 2 diabetes mellitus (T2DM).Methods The study objects were divided into T2DM group with cognitive dysfunction (group A,30 cases),T2DM group without cognitive dysfunction (group B,38 cases)and control group (68 healthy people undergoing physical examination).Serum CRP and UA levels as well as Montreal Cognitive Assessment (MoCA)score were compared among 3 groups.Results Groups A and B were evidently higher in serum CRP and UA levels but obviously lower in MoCA score than control group,and the differences were significant (P <0.01).Additionally,group A was marked-ly higher in serum CRP and UA levels but obviously lower in MoCA score than group B (P <0. 01).Conclusion Serum CRP and UA levels increase apparently and are in positive association with cognitive dysfunction of elderly T2MD patients,indicating that the detection of both indexes has important clinical value in predicating and diagnosing cognitive dysfunction of diabetes.