腹腔镜胃癌根治术的疗效及对患者免疫功能的影响

石旭峰, 徐飞

石旭峰, 徐飞. 腹腔镜胃癌根治术的疗效及对患者免疫功能的影响[J]. 实用临床医药杂志, 2014, (13): 133-134,137. DOI: 10.7619/jcmp.201413045
引用本文: 石旭峰, 徐飞. 腹腔镜胃癌根治术的疗效及对患者免疫功能的影响[J]. 实用临床医药杂志, 2014, (13): 133-134,137. DOI: 10.7619/jcmp.201413045
SHI Xufeng, XU Fei. Efficacy of laparoscopic radical operation for gastric cancer and its influence on the immune function[J]. Journal of Clinical Medicine in Practice, 2014, (13): 133-134,137. DOI: 10.7619/jcmp.201413045
Citation: SHI Xufeng, XU Fei. Efficacy of laparoscopic radical operation for gastric cancer and its influence on the immune function[J]. Journal of Clinical Medicine in Practice, 2014, (13): 133-134,137. DOI: 10.7619/jcmp.201413045

腹腔镜胃癌根治术的疗效及对患者免疫功能的影响

详细信息
  • 中图分类号: R735.2

Efficacy of laparoscopic radical operation for gastric cancer and its influence on the immune function

  • 摘要: 目的:分析探讨腹腔镜胃癌根治术的疗效及对患者免疫功能的影响。方法选取2010年1月-2012年7月于本院接受诊断和治疗的胃癌患者86例,随机分为观察组和对照组,每组43例。对照组给予传统开腹式胃癌根治术治疗,观察组给予腹腔镜胃癌根治术治疗,比较2组术中及术后恢复情况(术中出血量、首次排气时间、下床活动时间、止痛药物使用次数、首次进食时间和住院时间)、术后10 d 免疫功能(CD3+、CD4+、CD8+、CD4+/CD8+水平和 NK 细胞百分比)改变情况,以及术后并发症发生情况。结果观察组患者在术中出血量、首次排气时间、下床活动时间、止痛药物使用次数、首次进食时间和住院时间方面均明显优于对照组,差异有统计学意义(P <0.05)。2组患者术后10 d 在 CD3+、CD4+、CD8+、CD4+/CD8+水平方面均明显降低,且观察组显著优于对照组,差异有统计学意义(P <0.05)。2组并发症发生情况比较差异无统计学意义(P <0.05)。结论腹腔镜胃癌根治术临床疗效显著,能明显改善术后恢复,并发症较少,且对机体免疫功能影响较小,值得临床推广应用。
    Abstract: Objective To explore efficacy of laparoscopic radical operation for gastric cancer and analyze its influence on immune function.Methods 86 patients with gastric cancer were ran-domly divided into observation group and control group,43 cases in each group.The control group received conventional open type gastric cancer treatment,while observation group received laparo-scopic radical gastrectomy treatment.Blood loss,the first exhaust time,ambulation time,the fre-quency of use of pain medications,first feeding time and length of stay were compared,and immune function after 10 days of treatment(CD3,CD4,CD8,CD4 /CD8 levels and the percentage of NK cells)as well as the incidence rate of postoperative complications were compared.Results Intraop-erative blood loss,the first exhaust time,ambulation time,the frequency of pain medications,first feeding time and hospital stay in the observation group were significantly better than the control group (P <0.05 ).10 days after treatment,CD3,CD4,CD8,CD4 /CD8 levels in both groups sig-nificantly reduced,and of which in the observation group were significantly better than the control group (P <0.05).There was no significant difference of complications between two groups (P <0.05).Conclusion Laparoscopic radical operation for gastric cancer can significantly improve post-operative recovery,reduce incidence of complications and cause less influence on immune function, so it is worthy of clinical application.
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出版历程
  • 发布日期:  2014-09-10

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