Abstract: Objective To explore the application of evidence-based nursing in children with bronchiolitis obliterans.Methods The materials of 15 children with bronchiolitis obliterans were fully assessed.Evidence-based nursing group was established and nursing problems were raised. According to clinical practice guidelines on bronchiolitis obliterans,characteristics of nursing com-bined with nursing experience were searched out.Combined with parental acceptance degree and nursing experience,intervention countermeasures were formulated by the nursing group to apply to the 15 patients.Results 15 patients were all got better and discharged after effective treatment and nursing.Conclusion The application of evidence-based nursing in clinical nursing of children with bronchiolitis obliterans can promote better rehabilitation,increase parental satisfaction and promote relationships between nurses and patients.