Abstract: Objective To explore the effect and side effects of dezocine combined with sufentanil in patient-controlled intravenous analgesia(PCIA)of elderly patients with radical resec-tion of gastroenteric tumor.Methods 60 elderly patients with selective radical operation for gas-troenteric tumor were randomly divided into dezocine combined with sufentanil group (group DS,n=30)and sufentanil group (group S,n =30).Continuous monitoring was used to record blood pressure,heart rate,respiratory rate and SpO2,the VAS scores during both silence and 90°turn over situation were recorded,and Ramsay scores at 4,8,16,24 and 48 hours after operation as well as the adverse reactions were compared.Results There were no significant differences of Ramsay score and VAS pain during silence between two groups,but there was a significant differ-ence of VAS pain under turn-over situation between two groups(P <0.05).In group SD,the in-cidence rates of side effects such as nausea,vomiting,dizziness and shivering were significantly low-er than those in group S(P <0.05).Conclusion Application of dezocine combined with sufentanil has a preferable therapeutic effect for post-operative movement pain and less adverse effects,and it is worthy of clinical application and popularization.