Abstract: Objective To observe the impact of olmesartan and alprostadi on diabetic pa-tients with microalbuminuria.Methods 40 patients were divided into group A given olmesartan and B group given olmesartan and alprostadil.The two groups were treated for 2 weeks.The changes of microalbuminuria 、glomerular filtration rate,blood pressure,high-sensitivity C-reactive protein and blood clotting were observed.Results During the treament,there was statistically significant in the effect of microalbuminuria in group B than that in group A;There were signifi-cant difference in two groups of glomerular filtration rate,blood pressure,high-sensitivity C-reac-tive protein,and there was no significant difference in two groups of clotting change.Conclusion In group B,reduced microalbuminuria,glomerular filtration rate,blood pressure,high-sensitivity C-reactive protein was related with inhibition of the renin-angiotensin,and related to anti-kidney local hypercoagulable and micro-inflammatory state.