Abstract: Objective To investigate clinical significance of detection of serum high sensitiv-ity C-reactive protein (hs-CPR)of patients with primary hypertension.Methods A total of 152 patients with primary hypertension were divided into 3 groups according to the classification of hy-pertension.All patients were suggested to have low-salt and low-fat diet and proper physical exercise and received antihypertensive therapy.After half a year,hs-CPR levels before and after observation period were analyzed and compared with healthy people.Results Levels of hs-CRP before and after observation period were higher than that of healthy people (P <0.01).The hs-CRP levels of level 2 and level 3 of hypertension were obviously higher than level 1 of hypertension before grouping(P <0.05).After observation period,hs-CRP levels of level 1,level 2 and level 3 of hypertension were significantly lower than that before grouping in each group (P <0.05)while level 2 and level 3 were markedly higher than that of level 1 (P <0.05).Conclusion Primary hypertension has ob-viously increased hs-CRP and hs-CRP,so they have a strong relationship with the occurrence of hy-pertension.Therefore,effective control of blood pressure can obviously reduce the hs-CRP level.