Abstract: Objective To investigate the levels of serum resistin and hypersensitive c-reac-tive protein (hs-CPR)in patients with acute coronary syndrome (ACS).Methods 70 patients with ACS were selected as ACS group and subdivided into unstable angina pectoris (UAP)group,st-segment elevation myocardial infarction (STEMI)group and non st-segment elevation myocardial infarction (NSTEMI)group.35 people with health examination were selected as control group. Levels of serum resistin and hr-CPR were observed at 1,3,7,14 days after chest pain occurred. Results Levels of serum resistin and hs-CPR in ACS group at different time (1,3,7,14 days af-ter chest pain occurred)were significantly higher than those in control group (P <0.05)and peaked at 3 days.There was a positive correlation between levels of serum resistin and hr-CPR (P<0.01).3 days after chest pain occurred,the level of serum resistin in STEMI group and NSTE-MI group was significantly than that in UAP group (P <0.05).Conclusion Serum resistin and hs-CPR play a significant role in development and progress of ACS.