急性冠脉综合征患者血清抵抗素和超敏C反应蛋白水平及临床意义

王剑, 吴媛

王剑, 吴媛. 急性冠脉综合征患者血清抵抗素和超敏C反应蛋白水平及临床意义[J]. 实用临床医药杂志, 2014, (16): 156-158. DOI: 10.7619/jcmp.201416051
引用本文: 王剑, 吴媛. 急性冠脉综合征患者血清抵抗素和超敏C反应蛋白水平及临床意义[J]. 实用临床医药杂志, 2014, (16): 156-158. DOI: 10.7619/jcmp.201416051
WANG Jian, WU Yuan. Levels and significance of serum resistin and hypersensitive C-reactiveprotein in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2014, (16): 156-158. DOI: 10.7619/jcmp.201416051
Citation: WANG Jian, WU Yuan. Levels and significance of serum resistin and hypersensitive C-reactiveprotein in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2014, (16): 156-158. DOI: 10.7619/jcmp.201416051

急性冠脉综合征患者血清抵抗素和超敏C反应蛋白水平及临床意义

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R714.252

Levels and significance of serum resistin and hypersensitive C-reactiveprotein in patients with acute coronary syndrome

  • 摘要: 目的:探讨急性冠脉综合征(ACS)患者血清抵抗素和超敏 C 反应蛋白(hs-CRP)水平的动态变化及临床意义。方法 ACS 患者70例根据发病类型细分为不稳定型心绞痛组(UAP 组,25例)、急性 ST 段抬高型心肌梗死组(STEMI 组,25例)和急性非 ST 段抬高型心肌梗死组(NSTEMI 组,20例),同时选取35例健康体检人员为对照组。分别检测对照组和 ACS 组患者胸痛发作后1、3、7、14 d 的血清抵抗素和 hs-CRP 水平。结果不同时间点下 ACS 组患者血清抵抗素与 hs-CRP 水平均显著高于对照组(P <0.05),且血清抵抗素与 hs-CRP 水平在3 d 达到最大值;ACS 组患者血清抵抗素水平与 hs-CRP 水平呈正相关(P <0.01);胸痛发作3 d 时,STEMI 组、NSTEMI 组患者血清抵抗素水平均显著高于 UAP 组(P <0.05)。结论血清抵抗素与 hs-CRP 共同参与了 ACS 的发生发展,二者水平变化可能与 ACS 病情严重程度相关。
    Abstract: Objective To investigate the levels of serum resistin and hypersensitive c-reac-tive protein (hs-CPR)in patients with acute coronary syndrome (ACS).Methods 70 patients with ACS were selected as ACS group and subdivided into unstable angina pectoris (UAP)group,st-segment elevation myocardial infarction (STEMI)group and non st-segment elevation myocardial infarction (NSTEMI)group.35 people with health examination were selected as control group. Levels of serum resistin and hr-CPR were observed at 1,3,7,14 days after chest pain occurred. Results Levels of serum resistin and hs-CPR in ACS group at different time (1,3,7,14 days af-ter chest pain occurred)were significantly higher than those in control group (P <0.05)and peaked at 3 days.There was a positive correlation between levels of serum resistin and hr-CPR (P<0.01).3 days after chest pain occurred,the level of serum resistin in STEMI group and NSTE-MI group was significantly than that in UAP group (P <0.05).Conclusion Serum resistin and hs-CPR play a significant role in development and progress of ACS.
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出版历程
  • 发布日期:  2014-09-10

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