Abstract: Objective To investigate clinical effects of interferon combined with neoadju-vant chemotherapy on ovarian cancer complicated with ascites.Methods A total of 50 patients with ovarian cancer complicated with ascites admitted in the first hospital of the China Medical U-niversity during 2010 to 2012 were analyzed retrospectively.Totally 25 patients were treated by preoperative neoadjuvant chemotherapy with TPI(docetaxel,carboplatin and interferon)regimen, and others received TP(docetaxel and carboplatin)regimen.The resections were taken after 2 cy-cles of treatment.The remission of the clinical symptoms,side effects of chemotherapy,resection rate of satisfaction and resection situations was analyzed.Results The efficacy rates of TPI and TP regimen were 64% and 52% respectively.There was no significant difference between the two groups(P <0.05).But the reduction of ascites of TPI regimen was faster.The resection rate of satisfaction was no significant difference between the two groups,while the resection situations of TPI regimen were better.Some of side effects in TP regimen,such as bone marrow suppression, were slighter than TPI regimen.Conclusion Patients with ovarian cancer complicated with as-cites could relieve symptoms and resection situations from interferon combined with neoadjuvant chemotherapy,shorten operative time and bleeding,but increase the adverse effects.