Abstract: Obj ective To explore the relationship between xeroderma pigmentosum group D (ERCC2/XPD),Bcl-2 associated athanogene 1 (BAG-1 )and DNA repair gene RAD5 1 polymor-phism and clinicopathological characteristics of non-small cell lung cancer (NSCLC).Methods A case-control study with 100 NSCLC cases and 80 controls matched by age and sex was conducted, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP )was ana-lyzed.Logistic regression model was made to calculate the odd ratios (ORs)and detect 95%confi-dence intervals (CIs)of ERCC2/XPD Lys751Gln,BAG-1codon 324 and RAD51 codon 135 with susceptibility of NSCLC.Unconditional Logistic regression model adj usted by the confounding fac-tors was used to analyze the correlation between the polymorphism genotypes and the risk of NSCLC and clinicopathological characteristics.Results The odds ratios for individuals carrying ERCC2/XPD C/A and A/A were 1.53(95%CI:1.15~3.32)and 0.58 (95% CI:0.15~2.39).The odds ratios for individuals carrying BAG-1 C/T was 1.28(95%CI:1.08~2.74).The odds ratios for individuals carrying RAD51 G/C was 1.03(95%CI:1.06~2.29).ERCC2/XPD C/A and A/A polymorphisms genotype frequencies were significantly related to the invasive characteristics of NSCLC lymph node metastasis:(P= 0.038,OR= 2.26,95% CI:1.69~3.59),distant metastasis:(P= 0.005,OR= 2.47,95%CI:1.38~4.24).As the same BAG-1 codon 324 C/T and RAD51 codon 135 G/C polymorphisms genotype frequencies (P= 0.042,OR= 2.57, 95%CI:1.62~4.44 and P= 0.049,OR= 2.86,95%CI:1.39~3.62).Conclusion Genet-icpolymorphism of ERCC2/XPD,BAG-1 and RAD5 1 are associated with the susceptibility to NSCLC.ERCC2/XPD,BAG-1 and RAD51gene polymorphism in Chinese Han population in-creases susceptibility to NSCLC risk and the changes of ERCC2/XPD C/A and A/A,BAG-1codon 324 C/T and RAD51 codon 135 G/C polymorphism are closely related to lymph node and distant metastasis.