Abstract: Objective To observe the expression and clinical significance of nuclear factorκB 65 (NF-κB65 ),intercellular adhesion molecule-1 (ICAM-1 )and vascular cell adhesion molecule-1 (VCAM-1 )in the placenta tissue of patients with pregnancy-induced hypertension syndrome (PIH). Methods 58 PIH patients received institutional delivery were designed as PIH group and 40 normal materials of the same period were designed as control group.Expression of NF-κB65、ICAM-1 and VCAM-1 in endothelial cells and trophoblast cells from villous capillary of placenta tissue of both groups were determined by using immunohistochemistry.Results The positive expression rate and ex-pression intensity in PIH group were significantly better than control group (P<0.05 or P<0.01 ). While the positive expression rate and expression intensity gradually increased with aggravation of PIH. Correlation analysis showed the expression intensity of NF-κB65 was significantly and positively correlated with that of ICAM-1 and VCAM-1 in capillary endothelial cells of PIH patients (r =0 .9 5 1 , 0.894,P<0.01 ).The expression intensity of NF-κB65 was significantly and positively correlated with that of ICAM-1 in villous trophoblast cells (r=0.801,P<0.01).Conclusion The expression of NF-κB 6 5 ,ICAM-1 and VCAM-1 increases or decreases significantly in placental capillary endothelial cells and trophoblastic cells of PIH patients.Activation of NF-κB65 may regulate the expression of ICAM-1、VCAM-1 and involved in the development of PIH.