Abstract: ABSTRACT:Objective To compare effect of different wetting liquid after tracheotomy on airway humidification.Methods A total of 80 patients were randomly divided into the study group (n =40)and control group (n =40).The study group was treated with 0.45% sodium chloride solution to humidify airway while the patients in the control group were given airway hu-midification water for injection.Wet effect,sputum viscosity,respiratory mucosal bleeding,irri-tating cough and lung infections and other complications were observed.Results In the control group,better humidification effect was in 33 cases (82.5%),humidification deficiency was in 4 cases (10.0%),excessive wet was in 3 cases (7.5%).In the study group,better humidification effect was in 35 cases (87.5%),humidification deficiency was in 2 cases (5.0 %),excessive wet was in 3 cases (7.5%).The result revealed that the difference was not statistical significant (P >0.05).Ⅰ degree sputum viscosity in the control group accounted for 60.0%,Ⅱdegree accounted for 25.0%,Ⅲ degree accounted for 62.5% and 15.0%,25.00% and 12.50% in the study group respectively,which showed no statistical difference(P >0.05).Respiratory tract bleeding occurred in 13 cases in the control group and 3 cases in the study group,irritating cough in 13 cases in the control group and 3 cases in the study group,pulmonary infection in 16 cases and 6 cases in the study group ,the comparison result revealed that the difference was statistical significant (P <0.05).Conclusion 0.45% sodium chloride solution and injective water after tracheotomy for air-way humidification achieve good effect,but the complications of 0.45% sodium chloride solution is lower,so it is worthy of clinical application.