Abstract: ABSTRACT:Objective To explore the application effect of self-made inflatable mattress in thyroid surgery.Methods A total of 100 patients undergoing thyroid surgeries were randomly di-vided into control group and test groups with 50 cases in each of group.The control group was per-formed surgery with foam position pad on mattress with the area from (50×43×8)cm to (50×43 ×12)cm at 20 degree angles.The test group was performed surgery with controllable self-made inflatable mattress.Blood pressure,heart rate in different positions,comfort degree of surgery pa-tient and satisfaction index was recorded.Results There was no significant difference (P >0.05) between control group and test group in blood pressure and heart rate.Blood pressure and heart rate of patients of surgery in test group were lower than that of control group (P <0.05).There were statistically significant differences since comfort degree of surgery patient and satisfaction in-dex in control group were less than that of test group (P <0.05).Conclusion Controllable self-made inflatable mattress could avoid the changes in vital signs and remain a stable hemodynamics and improve comfort degree of patients and satisfaction index.