Abstract: Objective To explore the relevant influencing factors of the prognosis of patients with maintenance hemodialysis (MHD).Methods Totally 105 patients with MHD were followed up for two years.Their clinical data were collected,and follow-up results were recorded.The relationships between C-reactive protein (CRP),serum cardiac troponin T (cTnT) and the prognosis of patients with MHD were analyzed.Results A total of 105 patients with MHD were followed up for (20.68 ± 1.32) months,in which there were 27 cases (25.71％) with positive cTnT,31 cases (29.52％) with positive CRP,and 15 cases (14.29％) with positive cTnT and CRP.Twenty-one cases (20.00％) were dead in follow-up period.The mortality of patients with sample positive cTnT or CRP was significantly higher than those with sample negative cTnT or CRP (P ＜ 0.01),and the mortality of patients with both positive cTnT and CRP was markedly higher than those with both negative ones and those with one positive and one negative (P ＜ 0.05 or P ＜0.01).Survival analysis revealed that the survival of patients with MHD was significantly correlated with the influence of positive cTnT,positive CRP and positive cTnT and CRP.Conclusion The levels of serum cTnT and CRP are significantly correlated with the prognosis of patients with MHD.