Abstract: Objective To analyze the influence of human papilloma virus (HPV) infection on puerperas and fetus in pregnant women.Methods A total of 116 pregnant women with infection of human papilloma virus were selected as experimental group,while 116 healthy pregnant women were selected as control group.Parturient in amniotic fluid,placenta and fetal umbilical venous blood,oropharyngeal secretion and vulva secretion of HPV were detected,and maternal HPV infection type was analyzed.After one year of follow up,the effect of HPV infection on maternal and fetal were observed.Results In the experimental group,single HPV infection and high-risk HPV infection were the main types,and the proportions were 66.38％ and 76.72％ respectively.The risk factors of HPV infection were cervical abnormality and cytology examination.There were no significant differences in the mode of delivery,postpartum hemorrhage and fetal growth restriction (P ＞ 0.05).There were no significant differences in the HPV positive rates in the amniotic fluid,placenta and umbilical venous blood,oropharynx,vulva secretion or wrapping secretion between fetus with normal vaginal delivery and cesarean delivery (P ＞ 0.05).The infection rate of fetal HPV was 24.14％.Conclusion Single type HPV infection and high risk type HPV infection are the main types in pregnant women with HPV infection.