Correlation between breast ultrasound data classification system and estrogen receptor, progesterone receptor, proto-oncogene
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摘要: 目的 探讨乳腺超声数据分级系统(BI-RADS)与雌激素受体(ER)、孕激素受体(PR)以及原癌基因Cerb-2)的相关性.方法 分析320例经手术治疗及术后病理证实为乳腺癌患者的IDC超声影像表现,包括肿块的大小、边缘毛刺征、纵横比、有无微钙化、肿块后方回声有无衰减、肿块内部血流情况、弹性评分以及肿块BI-RADS分类,术后免疫组化检测ER、PR、CerB-2的表达情况.结果 边缘有毛刺征肿块的ER、PR阳性率明显高于边缘无毛刺征肿块,有微钙化肿块的Cerb-2表达阳性率高于无钙化肿块,血流分级为Ⅱ～Ⅲ级肿块的Cerb-2阳性率高于0～I级肿块;ER、PR、CerbB-2表达阳性肿块的BI-RADS分类显著高于ER、PR、CerbB-2表达阴性肿块(P＜0.05).结论 边缘毛刺征、微钙化、血流丰富与乳腺癌的分子生物学性征有一定的联系.Abstract: Objective To explore the correlation between breast ultrasound data classification system (BI-RADS) and estrogen receptor (ER),progesterone receptor (PR),proto-oncogene (Cerb-2).Methods The IDC ultrasound imaging of 320 patients diagnosed as breast cancer by surgery and postoperative pathology wasanalyzed,including the size of the lump,edge burr,aspect ratio,the presence of microcalcification,mass internal blood flow of posterior acoustic attenuation,mass,elasticity ratings and mass BI-RADS classification,and the expressions of ER,PR and CerB-2 were detected by immunohistochemical method.Results The positive rates of PR and ER in the mass with burr edge were significantly higher than those in the mass without burr edge,the positive rate of Cerb2 in mass with slight calcifications was significantly higher than that in mass without slight calcifications,and the positive rate of Cerb-2 in mass with flow grade Ⅱ ～Ⅲ was significantly higher than that in mass with flow grade 0 ～ I.The expressions of BI-RADS in mass with positive ER,PR and CerbB2 were significantly higher than those in mass with negative ER,PR and CerbB-2 (P ＜ 0.05).Conclusion There are correlations between molecular biology of breast cancer and edge burr,microcalcification and rich blood flow.
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Keywords:
- breast cancer /
- ultrasound /
- pathology
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期刊类型引用(10)
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