Abstract: Objective To investigate application of rehabilitation care guidance based on Orem-based self-care theory for cerebral infarction patients with hemiplegia.Methods A total of 582 patients with cerebral infarction confirmed by CT were randomly divided into observation group (n =291) and control group (n =291).Patients in the control group used conventional method,and the observation group was given rehabilitation nursing intervention based on Orem self-care theory.Hospitalization time,cost of hospitalization,the muscle strength and aphasia function at discharge were compared.The Social Support Rating Scale (SSRS),Self-rating Anxiety Scale (SAS),and the Index of Daily Life (ADL) were applied to respectively assess the level of social support,anxiety,and self-care ability.Results After treatment,hospitalization time and hospitalization costs in the observation group were lower than the control group,muscle strength,aphasia function,level of social support,anxiety and self-care ability were significantly better than the control group,and the differences were statistically significant (P ＜ 0.05).Conclusion Rehabilitation care guidance based on Orembased self-care theory can significantly shorten hospital stays,reduce treatment costs and anxiety,and improve the level of social support,quality of life and daily self-care ability.