Abstract: Objective To explore effect of cognitive intervention on improving cognitive impairment and quality of life of patients with Alzheimer disease.Methods A total of 160 Alzheimer's disease patients in our hospital randomized into experimental group and control group,with 80 cases in each group.The control group received routine nursing intervention,and the experimental group received cognitive intervention on the basis of the control group,quality of life,cognitive function,motor function and independent living rate were compared.Results After three months and six months of intervention,quality of life score of two groups was greatly improved compared with intervention before,and the experimental group improved more than the control group (P ＜ 0.05).After intervention,the experimental group had better cognitive function and motor function than the control group,the difference was statistically significant (P ＜ 0.05).Independent rate of the experimental group was significantly better than the control group (P ＜ 0.05).Conclusion The cognitive intervention can delay further development of disease,control clinical condition,reduce dependence on others,reduce the degree of limb disuse,and improve motor function,which can effectively improve cognitive function impairment and quality of life of patients with Alzheimer disease.