Abstract: Objective To study the effect of nursing intervention on awake time and blood ammonia levels for patients with hepatic encephalopathy treated by dialysis therapy.Methods A total of 60 patients with hepatic encephalopathy treated by dialysis therapy in our hospital were randomized into control group (routine nursing) and observation group (nursing intervention) according to random number method,with 30 patients per group.The incidence of induced factors of hepatic encephalopathy,the clinical efficacy of nursing,and the patients' awake time and changes of blood ammonia levels in two groups were compared.Results Compared with the control group,the incidences of induced factors of hepatic encephalopathy such as infection,high protein diet,gastrointestinal bleeding,electrolyte disturbances were significantly reduced in the observation group (P ＜ 0.05);Compared with the control group,the total effective rate of nursing was obviously increased in the observation group (P ＜ 0.05);The patients'awake time was significantly decreased and the blood ammonia levels were obviously reduced on after nursing in the observation group (P ＜ 0.05).Conclusion Nursing intervention for patients with hepatic encephalopathy can effectively remove the induced factors of hepatic encephalopathy and increase the clinical efficacy of dialysis therapy.