Abstract: Objective To study antihypertensive effect of comprehensive intervention in elderly patients with hypertension.Methods A total of 80 patients in our hospital were randomly divided into intervention group (n =41) and control group (n =39).The control group received antihypertensive drug treatment and basic nursing including blood pressure monitoring,prevention of complications and so on.Base on the control group,the intervention group was given exercise intervention,dietary intervention and health education,etc.according the patient's situation.Antihypertensive effect,blood pressure changes,the incidence of stroke events and adverse reactions before and after intervention were observed.Results Both the systolic blood pressure and diastolic blood pressure were decreased after intervention in the two groups.The difference in systolic blood pressure and diastolic blood pressure of two groups was statistically significant (P ＜ 0.05).The response rate of intervention group was 90.24％,which was significantly higher than 66.67％ of the control group (P ＜ 0.05).The incidence of stroke in the intervention group was 4.88％,which was lower than 20.51％ in the control group (P ＜ 0.05).Conclusion The comprehensive intervention could effectively improve the clinical effect,control the blood pressure level,improve the quality of life and reduce the incidence of adverse events in elderly patients with hypertension.So it is worth to be popularized.