Abstract: Objective To study the nursing measures of puncture point bleeding of lung cancer patients with PICC.Methods Clinical data of 56 lung cancer patients with PICC in our hospital was retrospective analyzed,causes of bleeding of puncture point was summarized and corresponding nursing countermeasures were implemented.Results Out of 56 patients with PICC,50 patients were successfully catheterized,there were 11 patients with puncture point bleeding after catheter,but bleeding was stopped and there was no re-catheterization after nursing.Scores of nursing service attitude were (91.25 ± 1.12) points,scores of nursing operation ability was (89.54 ± 2.45) points,nurse-patient communication score was (90.14 ± 1.41) points,health education score was (90.31 ± 2.56) points.And patients were generally satisfied with nursing.Conclusion Nursing staff should remove puncture point bleeding,exudates and blood for patients,replace sterile dressing,and repeat pressure and hemostasis.Situation of the puncture site are viewed again after 24 hours of properly fixing,and catheter is not affected after timely treatment.