Abstract: Objective To explore nursing effect of comprehensive nursing intervention on nursing efficacy and complication prevention for hemodialysis patients with uremia.Methods A total of 124 patients in our hospital were randomly divided into observation group and control group,given comprehensive nursing intervention and routine nursing.SDS score after treatment,heart failure occurrence rate and left ventricular ejection fraction (LVEF),6 min walking distance,left ventricular short neck relationship (FS),satisfaction and negative emotion of two groups were compared.Resuits After intervention,SDS score was significantly higher in the observation group;The indicators such as 6 minutes walking distance,heart rate,blood pressure,FS,LVEF and overall nursing satisfaction were significantly better than the control group,and the differences were statistically significant (P ＜ 0.05).Conclusion Comprehensive nursing intervention for uremia patients with hemodialysis can effectively improve compliance and treatment effect,effectively control complications,and improve patients'nursing satisfaction,so it is worth promoting.