Abstract: Objective To investigate the effect of different oxygen supply methods in the treatment of patients with tracheal incision after brain tumor surgery.Methods A total of 60 tracheotomy patients with brain tumor in our hospital were divided into nasal catheter group,artificial nose group,mask group,with 20 cases in each group,given therapy of nasal catheter oxygen,artificial nose oxygen and mask oxygen inhalation,respectively.Blood oxygen saturation,sputum viscosity (Ⅲ),and complications (pulmonary infection and incision infection) before oxygen and at 1,24 h of oxygen therapy were analyzed.Results Blood oxygen saturation was significantly increased at 1,24 h of oxygen therapy compared with inhalation before (P ＜ 0.05),but the mask group increased more than the other two groups (P ＜ 0.05).Sputum viscosity (Ⅲ) rate in nasal catheter group and mask oxygen inhalation group at 1,24 h of oxygen was significantly decreased compared with inhalation before (P ＜ 0.05),and was better than the artificial nose group (P ＜ 0.05).There was no significant difference in lung infection and incision infection in mask group and artificial nose group (P ＞ 0.05),but were significantly lower than nasal catheter group (P ＜ 0.05).Conclusion Oxygen mask used in brain tumor surgery patients with tracheotomy not only can quickly and steadily improve blood oxygen saturation,reduce sputum viscosity,pulmonary infection and incidence of wound infection,so it is worthy of promotion.