Abstract: Objective To explore the application effect of staged rehabilitation program in rehabilitation of patients after total knee replacement.Methods A total of 80 patients with total knee arthroplasty in our hospital were randomly divided into observation group and control group,the control group was given routine rehabilitation training,and the observation group was given staged rehabilitation guidance,rehabilitation of enthusiasm,postoperative knee function and life ability recovery were compared.Results Demand degree for rehabilitation,compliance and the coordination degree in the observation group were higher than that in the control group,and the differences were statistically significant (P ＜ 0.05).Postoperative knee function score,living ability score,knee function excellent rate in the observation group were higher than that in the control group,the differences were statistically significant (P ＜ 0.05).Conclusion Staged rehabilitation program can improve the enthusiasm,knee joint function and life ability,so it is worth promoting.