Abstract: Objective To explore perioperative nursing of excision with vertical and horizontal incision and repair of palpebral margin pigmented nevus.Methods Ten patients with palpebral margin pigmented nevus excision of vertical and horizontal incision and repair were selected as research objects,perioperative nursing and effect of palpebral margin pigmented nevus excision.Results The pathological examination showed it was benign lesions and postoperative incision of 10 patients was successful with eyes symmetrical in shape,normal eyes'open and close function,no complications,and no deformity.After followed up for 1 year after operation,there was no recurrence and obvious scar.Conclusion Excision with vertical and horizontal incision and repair of palpebral margin pigmented nevus is characterized by smaller wound surface,less complications,and better postoperative recovery.And it is crucial for success of surgery and postoperative recovery to carry out perioperative nursing.