Abstract: Objective To investigate the rehabilitation effect of folic acid,intravenous and oral lipoic acid sequential therapy combined with plantar acupoint massage on treatment of patients with high-risk diabetic foot (DF).Methods A total of 120 patients with high-risk DF were randomly divided into 4 groups.The control group was given routine therapy of diabetes.Besides the basic treatment,folic acid was given in the folic acid group.On the basis of the folic acid group,lipoic acid was used in lipoic acid group with oral taken after two weeks of intravenous drip.The massage group was treated with plantar acupoint massage on the basis of the lipoic acid group,and the treatment course was 6 months.The Toronto symptom and sign score,the brachial ankle pulse wave velocity (baPWV),the ankle brachial ratio (ABI) and the score of life quality of four groups were compared before and after the intervention.Results The homocysteine and the baPWV in the folic acid group,the lipoic acid group and the massage group were significantly lower than those in the control group (P ＜0.01).Except for the folic acid group,The Toronto symptom and sign score in the other two groups was significantly lower than that in the control group (P ＜ 0.01).Except for the folic acid group,ABI of the lipoic acid group and the massage group was significantly higher than that of the control group (P ＜0.01).The score of life quality in the lipoic acid group and the massage group were significantly lower than that in the control group (P ＜ 0.01).The oxidized low density lipoprotein in the lipoic acid group and the massage group were significantly lower than that in other two groups (P ＜ 0.01).Conclusion Folic acid,intravenous and oral lipoic acid sequential therapy combined with plantar acupoint massage can improve the effect of DF patients.