Abstract: Objective To explore the effect of low calcium dialysate on calcium and phosphorus metabolism and parathyroid hormone in patients with maintenance hemodialysis.Methods A total of 60 non-hypocalcemia patients with maintenance hemodialysis were randomly divided into observation group and control group.The observation group was treated with low calcium dialysate (Ca2 + concentration was 1.25 mmol/L),while the control group was treated with conventional calcium dialysate (Ca2 + concentration was 1.50 mmol/L).Effect was compared between two groups.Results After treatment,the serum T-Ca,T-Ca × P significantly decreased in the observation group,and serum iPTH significantly increased (P ＜ 0.05).In the control group,the serum T-Ca,T-Ca x P significantly increased,and serum iPTH decreased significantly (P ＜ 0.05).The serum levels of TCa,T-Ca x P in the observation group were significantly lower than those in the control group,and the serum iPTH level was significantly higher than that in the control group (P ＜ 0.05).After 6 months of treatment,the serum hs-CRP level of the observation group was significantly lower than that of the control group (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P ＞ 0.05).Conclusion Application of low calcium dialysate can decrease serum high calcium loading,improve the status of excessive inhibition of parathyroid hormone and cardiovascular inflammation status in treatment of non-hypocalcemia patients with maintenance hemodialysis.