Abstract: Objective To explore effects of three different anesthetic methods on cerebral oxygen partial pressure and cerebral oxygen metabolism in patents with severe traumatic brain injury.Methods A total of 78 patients with severe traumatic brain injury were randomly divided into group A (total intravenous anesthesia),group B (sevoflurane inhalation anesthesia) and group C (combined inhalation and intravenous anesthesia).Mean arterial pressure (MAP),heart rate (HR),jugular vein blood oxygen content (CjvO2),radial artery blood oxygen content (CaO2) and cerebral extraction of oxygen (CERO2) were observed in all groups at the time points of pre intubation (T0),pre anesthesia induction (T1),2 minutes after anesthesia induction (T2),10 minutes after surgery begin (T3),30 minutes after surgery begin (T4),end of surgery (T5).Results Compared with T0 and T1,MAP in all groups at T2 to T5 significantly decreased (F =5.112,4.040,4.301;P =0.0002,0.0018,0.0011).In all groups,SjvO2 significantly increased after anesthesia (F =3.833,3.322,8.114;P=0.0027,0.0071,＜0.0001),Da-jvO2(F=3.127,2.635,4.886;P=0.0094,0.0258,0.0004) and CERO2 (F =14.37,8.805,25.72;P ＜ 0.01) significantly decreased.Conclusion Propofol intravenous anesthesia,sevoflurane inhalation anesthesia and general anesthesia combined with intravenous anesthesia have good brain protection effects.