Abstract: Objective To observe the short-term efficacy and side effects of vinorelbine combined with cisplatin regimen in the treatment of patients with relapsed and metastatic breast cancer.Methods Clinical materials of 62 patients with relapsed and metastatic breast cancer were analyzed retrospectively,and they were treated with vinorelbine and cisplatin.Adverse events were recorded and efficacy was evaluated.Results The total effective rate was 59.68％ (37/62).The total clinical benefit rate was 90.32％ (56/42).The main adverse reactions were myelosuppression and gastrointestinal response.Conclusion NP regimen is effective in the treatment of patients with relapsed and metastatic breast cancer,and patients can tolerate the adverse reactions.