Abstract: Objective To explore the clinical effects of ligation for descending branch of uterine artery combined with lower uterine compression and coarctation suture in treatment of patients with postpartum hemorrhage caused by dangerous placenta previa.Methods A total of 220 patients with dangerous placenta previa were randomly divided into the observation group (n =110) and the control group (n =110).The observation group was treated with descending branch of uterine artery ligation combined with lower uterine compression and coarctation suture,and the control group was treated with B-Lynch suture combined with inferior segment gauze packing.The operation time,intraoperative bleeding volume,postoperative 24 h bleeding,preoperative hemoglobin,postoperative hospitalization time,correction of hemoglobin,oxytocin and carboprost ammonia butyl alcohol three dosage,blood transfusion,uterine artery embolization,uterine resection rate were compared between the two groups.Results The operation time of the observation group was significantly shorter than the control group,the amount of intra-operative bleeding and postoperative 24 h blood loss were significantly less than the control group,postoperative correction of hemoglobin was significantly higher than the control group (P ＜0.01),and hemoglobin had no significant difference between the two groups before operation (P ＞ 0.05).In the observation group,hospitalization time was significantlyshorter than the control group,carboprost in ammonia butyl alcohol three dose was significantly lower than the control group (P ＜ 0.0 1),but the oxytocin dose had no significant difference between two groups (P ＞ 0.05).In the observation group,blood transfusion rate,uterine artery embolization rate and hysterectomy rate were 40.4％,2.7％ and 1.8％,which were significantly lower than 59.1％,10.9％ and 10％ in the control group (P ＜ 0.05).Conclusion Ligation for descending branch of uterine artery combined with lower uterine compression and coarctation suture can effectively improve the successful rate of surgery.