妊娠期高血压患者血清脂联素与胎盘基质金属蛋白酶-9的相关性研究

张艳; 凃静; 黄晖

doi:10.7619/jcmp.201703029

妊娠期高血压患者血清脂联素与胎盘基质金属蛋白酶-9的相关性研究

湖北省恩施市中心医院妇产科,湖北恩施,445000

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中图分类号: R714.14
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出版历程

Study on the correlation between serum adiponectin and placental matrix metalloproteinase 9 in patients with gestational hypertension

摘要

摘要: 目的探讨妊娠期高血压患者血清脂联素水平与胎盘基质金属蛋白酶-9(MMPO)的关系.方法根据疾病严重程度,将145例妊娠期高血压孕妇分为轻度妊高征组72例和重度妊高征组73例,以同期正常分娩的孕妇60例为对照组,比较各组血清脂联素水平与MMP-9的表达情况.结果妊高征各组与对照组血清脂联素比较均下降(P＜0.05).妊高征各组与对照组MMP-9阳性率比较,差异有统计学意义(P＜0.05或P＜0.01);重度妊高征组MMP-9阳性率显著低于轻度妊高征组及对照组(P＜0.01).妊高征患者血清脂联素水平与胎盘MMP-9阳性表达率呈正相关(r=0.71,P＜0.05).结论血清脂联素水平降低及胎盘组织MMP-9表达率下降可能促进了妊娠高血压疾病的发生与发展.
- 妊娠期 /
- 高血压 /
- 脂联素 /
- 胎盘基质金属蛋白酶-9
Abstract: Objective To explore the relationship between the level of serum adiponectin and placental matrix metalloproteinase 9 (MMP-9) in patients with gestational hypertension.Methods According to the severity of disease,145 patients with gestational hypertension were divided into mild gestational hypertension group (n =72) and severe gestational hypertension group (n =73),and 60 healthy pregnant women at the same time were selected as control group.The levels of serum adiponectin and MMP-9 expression were compared among three groups.Results Compared with control group,the levels of serum adiponectin in gestational hypertension groups decreased significantly (P ＜ 0.05).There was significant difference between gestational hypertension groups and control group in the positive rate of MMP-9 (P ＜ 0.05 or P ＜ 0.01).The positive rate of MMP-9 in severe gestational hypertension group was significantly lower than that in mild one and control group (P ＜0.01).The level of serum adiponectin was positively correlated with placental MMP-9 in the patients with gestational hypertension (r =0.71,P ＜ 0.05).Conclusion The decrease of serum adiponectin and the decreased expression of MMP-9 in placenta may promote the occurrence and development of gestational hypertension.
- pregnancy /
- hypertension /
- adiponectin /
- placental matrix metalloproteinase 9

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1.	李莹莹，秦福杰，翁玲君. MMP-1、MMP-7水平与妊娠期高血压的关系. 河北医药. 2020(09): 1311-1314+1319 . 百度学术
2.	马超，汪韬，肖杨. 妊娠期高血压孕妇脐血流不同参数对宫内胎儿缺氧、胎儿生长受限的预测价值. 临床误诊误治. 2020(09): 92-96 . 百度学术
3.	虞琪，徐峰，王美林. 探讨APN水平检测在HDP患者病情严重程度判断和胎儿发育状态评估中的临床价值. 系统医学. 2019(17): 135-137 . 百度学术
4.	郑玉霞，孙秀云. 初次妊娠高血压患者血清HMWA水平对再次妊娠发生PIH的影响. 系统医学. 2018(18): 138-140 . 百度学术

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文章访问数: 250
HTML全文浏览量: 69
PDF下载量: 4
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妊娠期高血压患者血清脂联素与胎盘基质金属蛋白酶-9的相关性研究

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Study on the correlation between serum adiponectin and placental matrix metalloproteinase 9 in patients with gestational hypertension

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