Study on the correlation between serum adiponectin and placental matrix metalloproteinase 9 in patients with gestational hypertension
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摘要: 目的 探讨妊娠期高血压患者血清脂联素水平与胎盘基质金属蛋白酶-9(MMPO)的关系.方法 根据疾病严重程度,将145例妊娠期高血压孕妇分为轻度妊高征组72例和重度妊高征组73例,以同期正常分娩的孕妇60例为对照组,比较各组血清脂联素水平与MMP-9的表达情况.结果 妊高征各组与对照组血清脂联素比较均下降(P＜0.05).妊高征各组与对照组MMP-9阳性率比较,差异有统计学意义(P＜0.05或P＜0.01);重度妊高征组MMP-9阳性率显著低于轻度妊高征组及对照组(P＜0.01).妊高征患者血清脂联素水平与胎盘MMP-9阳性表达率呈正相关(r=0.71,P＜0.05).结论 血清脂联素水平降低及胎盘组织MMP-9表达率下降可能促进了妊娠高血压疾病的发生与发展.
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关键词:
- 妊娠期 /
- 高血压 /
- 脂联素 /
- 胎盘基质金属蛋白酶-9
Abstract: Objective To explore the relationship between the level of serum adiponectin and placental matrix metalloproteinase 9 (MMP-9) in patients with gestational hypertension.Methods According to the severity of disease,145 patients with gestational hypertension were divided into mild gestational hypertension group (n =72) and severe gestational hypertension group (n =73),and 60 healthy pregnant women at the same time were selected as control group.The levels of serum adiponectin and MMP-9 expression were compared among three groups.Results Compared with control group,the levels of serum adiponectin in gestational hypertension groups decreased significantly (P ＜ 0.05).There was significant difference between gestational hypertension groups and control group in the positive rate of MMP-9 (P ＜ 0.05 or P ＜ 0.01).The positive rate of MMP-9 in severe gestational hypertension group was significantly lower than that in mild one and control group (P ＜0.01).The level of serum adiponectin was positively correlated with placental MMP-9 in the patients with gestational hypertension (r =0.71,P ＜ 0.05).Conclusion The decrease of serum adiponectin and the decreased expression of MMP-9 in placenta may promote the occurrence and development of gestational hypertension.-
Keywords:
- pregnancy /
- hypertension /
- adiponectin /
- placental matrix metalloproteinase 9
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期刊类型引用(2)
1. 马利，马政权，马晓瑞，周娜，马楼艳. 维生素D受体BsmI位点与老年原发性高血压的相关性研究. 心肺血管病杂志. 2024(09): 991-997 . 
百度学术
2. 朱金玉，李燕，牛桂林. 南阳市儿童青少年血压升高现状及影响因素. 中国卫生工程学. 2021(02): 248-249+251 . 百度学术
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