Abstract: Objective To explore the level of uric acid and lipid metabolism in 120 patients with psoriasis and their clinical diagnostic significance.Methods A total of 120 patients with psoriasis were selected.Uric acid and blood lipids were detected.Levels of TC,TG,HDL-C,LDL-C,ApoA1,ApoB,uric acid were compared between psoriasis group and control group.Lipid metabolism in patients with different types of psoriasis was compared.Results The levels of TC,HDL-C and ApoA1 in the psoriasis group were significantly lower than those in the control group (P ＜ 0.05),and the level of TG was significantly higher than that of the control group (P ＜ 0.05).Levels of TC,HDL-C,LDL-C,ApoA1 and ApoB in psoriasis pustulosa group were significantly lower than the other two groups (P ＜ 0.05).Serum uric acid values of male and female in psoriasis group were significantly higher than the control group (P ＜ 0.05).Conclusion Analysis of uric acid,lipid metabolism in psoriasis patients has very important diagnostic significance.