Abstract: Objective To study changes of serum and scurf oxidative stress indicators,and hemorheology indicators of patients with psoriasis.Methods A total of 61 patients with psoriasis in hospital from December 2013 to January 2016 were selected as observation group,another 61 healthy of the same age at the same period were selected as control group,the serum and scurf oxidative stress indicators,hemorheology indicators of two groups were respectively detected and compared,and the detection results of above indicators of observation group with different severity and disease stages were compared.Results The serum and scurf SOD of observation group was lower (P ＜ 0.05),serum and scurf MDA,the hemorheology indicators and LPO were higher than that of control group (P ＜0.05),and the detection results of serum and scurf oxidative stress indicators,hemorheology indicators of observation group with different severity and disease stages showed significant differences (P ＜0.05).Conclusion The serum and scurf oxidative stress indicators,hemorheology indicators of patients with psoriasis are obviously differentiated from the healthy,so those indicators of the patients should be closely monitored.