Abstract: Objective To explore the effect of comprehensive nursing intervention on psychological state of chemotherapy patients with advanced non-small cell lung cancer.Methods A total of 108 patients of non-small cell lung cancer (NSCLC) received chemotherapy in our hospital were randomly divided into control group and observation group according to different nursing methods,the control group adopted routine nursing measures,and the observation group strengthened comprehensive nursing intervention on the basis of routine nursing measures.The mental state before and after intervention of two groups were compared.Results There was no significant difference in SCL-90 score,SAS score and SDS score between the two groups before nursing intervention (P ＞ 0.05).The score of SCL-90 in the observation group was significantly better than that in the control group (P ＜ 0.05).The score of SAS and SDS in the observation group were significantly lower than that in the control group (P ＜ 0.05).Conclusion Effective comprehensive nursing intervention can alleviate the anxiety and depression of patients with advanced non-small cell lung cancer,improve the patients' bad mood and treatment compliance.