Abstract: Objective To discuss the clinical efficacy of comprehensive nursing intervention for patients with type 2 diabetes.Methods A total of 65 patients with type 2 diabetes given conventional nursing from June 2013 to June 2014 were selected as control group and 71 patients given comprehensive nursing intervention from July 2014 to July 2015 were as observation group.Indicators of blood glucose,compliance,mastery degree of health knowledge and quality of life were compared between both groups.Results Patients' compliance and mastery of health knowledge were better than the control group.The degree of improvement in observation group was better than that in control group (P ＜ 0.05).After one year of intervention,a significant difference was seen in life quality and different indicators of two groups compared with the intervention before (P ＜ 0.05),and observation group was better then the control group (P ＜ 0.05).Conclusion Comprehensive nursing intervention can improve self-management and disease cognition level,improve blood glucose,and promote rehabilitation and life quality of patients with type 2 diabetes.