摘要:
目的 研究血液透析滤过对维持性血液透析患者微炎症和营养状态的影响.方法 选择维持性血液透析的终末期肾病患者300例,采用随机数字表法将患者随机分为2组,HDF组和HD组,各150例,分别于治疗前和治疗12周后采血检测2组患者微炎症指标,包括超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α),与营养指标,包括血清总蛋白(TP)、血清白蛋白(ALB)及血红蛋白(Hb)的变化.结果 HD组与HDF组患者治疗前hs-CRP、IL-6、TNF-α与TP、ALB及Hb差异均无统计学意义(P＞0.05);治疗后,HD组患者hs-CRP、IL-6、TNF-α水平较治疗前无显著改变(P＞0.05);HDF组治疗后血hs-CRP、IL-6、TNF-α水平较治疗前均显著下降(P ＜0.01);HD组和HDF组治疗后较治疗前TP、ALB及Hb均升高(P＜0.05).HDF组治疗后TP、ALB及Hb升高幅度较HD组明显(P＜0.05),hs-CRP、IL-6、TNF-α水平下降幅度较HD组显著(P＜0.05).结论 HDF治疗技术可有效清除维持性血液透析患者体内的中大分子炎症因子,改善微炎症状态,提高维持性血液透析患者的营养状态.
Abstract:
Objective To study the effect of hemodiafiltration on micro-inflammation and nutritional status in maintenance hemodialysis patients.Methods A total of 300 terminal renal disease(ESRD) patients with hemodialysis were randomly divided into HDF group(n =150) and HD group(n =150).The blood of serum albumin(Alb),total protein(TP),hemoglobin(Hb),high-sensitivity C-reactive protein (hs-CRP),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were determined by a biochemistry analyzer before and after 12 weeks of treatment.Results No significant differences was seen in hs-CRP,IL-6,TNF-α,TP,ALB and Hb between two groups before treatment(P ＞ 0.05).However,hs-CRP,IL-6 and TNF-α significantly decreased after the treatment in HOF group(P ＜0.01) but not in HD group.TP,ALB and Hb significantly increased after the treatment in the 2 groups (P ＜ 0.05).After the treatment,TP,ALB and Hb were higher in HOF group than in HD group (P ＜ 0.05),and hs-CRP,IL-6 and TNF-α were lower in HDF group than in HD group(P ＜ 0.05).Conclusion HDF can effectively clear the macromolecules inflammatory cytokines,alleviate the micro-inflammatory state,and improve nutritional status of MHD patients.
百度学术
下载:
苏公网安备 32100302010246号
