Abstract: Objective To investigate effect of specific psychological guidance in improving mental elasticity of intern undergraduates.Methods A total of 80 nursing interns were randomly divided into control group with regular courses and skills training,and experimental group with psychological guidance.Working pressure score,social support score,psychological symptoms score and mental elasticity score before and after intervention were compared.Results After nursing intervention,nursing and work,workload and time allocation,the working environment and resources,patient care,management and interpersonal skills,stress score,somatization,interpersonal sensitivity,depression,anxiety,hostility between terror,paranoia and psychosis scores in the experimental group were significantly lower than the control group,the objective and subjective support,support utilization,social support,firm,self-reliance,optimism and total scores of mental elasticity were significantly higher than the control group (P ＜ 0.01).Conclusion The effect of psychological counseling for nursing undergraduates is remarkable,and it is worthy of clinical application.