Expressions and significance of peripheral galectin-3 and N-terminal B-type brain natriuretic peptide in patients with chronic heart failure
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摘要: 目的 探讨慢性心力衰竭(CHF)患者外周血半乳糖凝集素(Gal)-3、N末端B型利钠肽原(NT-proBNP)表达水平的变化.方法 选择89例CHF患者,采用酶联免疫吸附法、电化学发光法分别检测入选患者外周血Gal-3、NT-proBNP表达水平,分析他们在不同类型心力衰竭、心功能分级患者中的变化.结果 HFPEF、HFREF患者Gal-3、NT-proBNP水平比较,差异均有统计学意义(P=0.000);心功能Ⅱ级、Ⅲ级、Ⅳ级患者Gal-3、NT-proBNP表达水平有显著差异(P =0.000);Gal-3与NT-proBNP呈正相关(r=0.230,P=0.030),与LVEF呈负相关(r=-0.533,P=0.000);NT-proBNP与LVEF呈负相关(r=-0.372,P=0.000).结论 外周血Gal-3、NT-proBNP可作为评判CHF患者病情危重程度的重要指标.Abstract: Objective To explore the change of peripheral galectin (Gal)-3 and N-terminal B-type brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure.Methods A total of 89 patients with chronic heart failure (CHF) were enrolled.Peripheral Gal-3,NT-proBNP were detected by enzyme-linked immunosorbent assay (ELISA) or Electrochemical luminescence method.The expression levels of Gal-3,NT-proBNP in patients with different kinds of heart failure and cardiac functional grading were analyzed.Results There were significant differences in expression levels of Gal-3 and NT-proBNP between patients with HFPEF and patients with HFREF.There was significant differences of Gal-3 and NT-proBNP in patients with NYHA heart function class Ⅱ,Ⅲ and Ⅳ.Gal3 was positively correlated with NT-proBNP (r =0.230,P =0.030) and negatively correlated with LVEF (r =-0.533,P =0.000).NT-proBNP was negatively correlated with LVEF (r =-0.372,P =0.000).Conclusion Peripheral Gal-3,NT-proBNP could be considered as two important markers for judging severity of illness in patients with CHF.
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Keywords:
- heart failure /
- chronic /
- Galectin-3
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期刊类型引用(11)
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9. 张建霞，杨培亮，王焕. 冠心病合并慢性心力衰竭患者GDF15、BNP、sST2的表达及其与心功能的相关性. 临床误诊误治. 2019(12): 67-71 . 百度学术
10. 盛洋，郑学敏，王伟，沈盛晖. 酒石酸美托洛尔片联合左卡尼汀注射剂治疗慢性心力衰竭的临床研究. 中国临床药理学杂志. 2018(04): 410-413 . 百度学术
11. 邓威. 血清Gal-3、NT-pro-BNP在慢性心力衰竭中的表达及临床意义. 中国民康医学. 2018(16): 20-21 . 百度学术
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