Abstract: Objective To study and observe the influence of naloxone on the respiratory function and blood gas analysis indexes of patients with respiratory failure.Methods A total of 58 patients with respiratory failure were selected and randomly divided into control group and observation group,29 cases in each group.The control group was treated with conventional treatment of respiratory failure,while the observation group was treated with naloxone on the basic treatment of control group.Then the respiratory function and blood gas analysis indexes before the treatment and at 12th,24th and 48th hour after the treatment were detected.Results The respiratory function and blood gas analysis indexes of observation group at 12th,24th and 48th hour after the treatment were significantly better than those of control group (P ＜ 0.05).Conclusion The naloxone can obviously improve the respiratory function and blood gas analysis indexes of patients with respiratory failure.