Abstract: Objective To explore the effect of non-invasive positive pressure ventilation (CPAP) on airway inflammation factors of patients with chronic obstructive pulmonary disease (COPD).Methods A total of 60 patients with COPD were randomly divided into control group (n =30) and observation group (n =30).The patients in the control group were treated with conven-tional symptomatic support.In the observation group,non-invasive positive pressure ventilation was applied on the basis of the control group.IL-8 and TNF-α were measured by enzyme-linked immunosorbent assay.The cell suspension,neutrophil percentage of white blood cells,clinical efficacy and the airway inflammatory factors were compared between two groups.Results After treatment,the levels of pH and p (O2) in the observation group were significantly higher than those in the control group (P ＜ 0.05),and the level of p (CO2) were significantly lower than the control group (P ＜ 0.05).There was no significant difference in neutrophil count before and after treatment between the two groups (P ＞ 0.05).The IL-8 and TNF-α in the observation group were significantly lower than those in the control group (P ＜ 0.05).The incidence rate of complications in the observation group was 3.33％,which was significantly lower than 10.00％ in the control group (P ＜ 0.05).Conclusion Combination of non-invasive positive pressure ventilation and conventional therapy is effective in treatment of patients with COPD.