Effect of non-invasive positive pressure ventilation on airway inflammatory factors of patients with chronic obstructive pulmonary disease
-
摘要: 目的 探讨无创正压通气对慢性阻塞性肺疾病患者气道炎症因子的影响.方法 选取慢性阻塞性肺疾病患者60例,采用随机数字法分为对照组和观察组各30例.对照组采用常规对症支持治疗,观察组在对照组基础上联合无创正压通气治疗.比较2组临床疗效,IL-8、TNF-α水平,中性粒细胞占白细胞百分比等指标.结果 观察组治疗后pH、p(02)水平显著高于对照组(P＜0.05),p(C02)水平显著低于对照组(P＜0.05).2组治疗前、后中性粒细胞占白细胞百分比无显著差异(P＞0.05).观察组治疗后IL-8、TNF-α显著低于对照组(P＜0.05).观察组治疗后并发症发生率为3.33％,显著低于对照组的10.00％ (P ＜0.05).结论 慢性阻塞性肺疾病患者在常规治疗基础上联合无创正压通气治疗效果理想.Abstract: Objective To explore the effect of non-invasive positive pressure ventilation (CPAP) on airway inflammation factors of patients with chronic obstructive pulmonary disease (COPD).Methods A total of 60 patients with COPD were randomly divided into control group (n =30) and observation group (n =30).The patients in the control group were treated with conven-tional symptomatic support.In the observation group,non-invasive positive pressure ventilation was applied on the basis of the control group.IL-8 and TNF-α were measured by enzyme-linked immunosorbent assay.The cell suspension,neutrophil percentage of white blood cells,clinical efficacy and the airway inflammatory factors were compared between two groups.Results After treatment,the levels of pH and p (O2) in the observation group were significantly higher than those in the control group (P ＜ 0.05),and the level of p (CO2) were significantly lower than the control group (P ＜ 0.05).There was no significant difference in neutrophil count before and after treatment between the two groups (P ＞ 0.05).The IL-8 and TNF-α in the observation group were significantly lower than those in the control group (P ＜ 0.05).The incidence rate of complications in the observation group was 3.33％,which was significantly lower than 10.00％ in the control group (P ＜ 0.05).Conclusion Combination of non-invasive positive pressure ventilation and conventional therapy is effective in treatment of patients with COPD.
-
-
期刊类型引用(4)
1. 王惠霞. 无创正压通气联合保金化痰利肺汤对慢阻肺急性加重期效果观察. 临床研究. 2024(01): 119-122 . 
百度学术
2. 岑坚兴，梁守敬，郑普光. 无创通气治疗老年COPD伴睡眠障碍的效果及对患者睡眠质量的影响. 世界睡眠医学杂志. 2022(05): 836-838 . 百度学术
3. 杨雍，吕汝琦，刘丹. 早期无创正压通气对重症急性胰腺炎合并肺损伤的保护作用机制. 医学信息. 2019(03): 55-57 . 百度学术
4. 李菡，周志刚. 无创正压通气联合呼吸兴奋剂治疗慢性阻塞性肺疾病合并肺性脑病的效果观察. 实用临床医药杂志. 2019(07): 68-71 . 本站查看
其他类型引用(0)
计量
- 文章访问数: 283
- HTML全文浏览量: 63
- PDF下载量: 4
- 被引次数: 4
下载:
苏公网安备 32100302010246号